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Digital microfluidics: A promising technique for biochemical applications

He WANG, Liguo CHEN, Lining SUN

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 4,   Pages 510-525 doi: 10.1007/s11465-017-0460-z

Abstract:

Digital microfluidics (DMF) is a versatile microfluidics technology that has significant application potential in the areas of automation and miniaturization. In DMF, discrete droplets containing samples and reagents are controlled to implement a series of operations via electrowetting-on-dielectric. This process works by applying electrical potentials to an array of electrodes coated with a hydrophobic dielectric layer. Unlike microchannels, DMF facilitates precise control over multiple reaction processes without using complex pump, microvalve, and tubing networks. DMF also presents other distinct features, such as portability, less sample consumption, shorter chemical reaction time, flexibility, and easier combination with other technology types. Due to its unique advantages, DMF has been applied to a broad range of fields (e.g., chemistry, biology, medicine, and environment). This study reviews the basic principles of droplet actuation, configuration design, and fabrication of the DMF device, as well as discusses the latest progress in DMF from the biochemistry perspective.

Keywords： digital microfluidics     electrowetting on dielectric     discrete droplet     biochemistry    

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Potential of electron transfer and its application in dictating routes of biochemical processes associated

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 679-692 doi: 10.1007/s11684-021-0866-1

Abstract: reprogramming could be predicted by examining the net changes of the PET values associated with the biochemical

Keywords： metabolic reprogramming     potential of electron transfer     cell proliferation     aerobic glycolysis     cancer metabolism    

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Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary cirrhosis: a 2-year follow-up study

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 255-263 doi: 10.1007/s11684-012-0227-1

Abstract: The biochemical response of patients at stage 2 was much better than that of patients at stages 3&ndashstage, patients in long-term administration of UDCA can gain favorable results not only on symptoms and biochemicalIt is also indicated that later histological stage, bad biochemical response and severe symptom may be

Keywords： primary biliary cirrhosis     ursodeoxycholic acid     Chinese     biochemical response     therapeutic efficacy    

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Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine

Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 90-99 doi: 10.15302/J-FASE-2015045

Abstract: We applied chromatography and mass spectrometry based metabonomics to assess system-wide metabolic response

Keywords： myostatin     transforming growth factor-β family     skeletal muscle     metabolic disorders     chromatography     mass spectrometry     metabonomics    

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Uptake and accumulation of multiwalled carbon nanotubes change the morphometric and biochemical characteristics

Elena SMIRNOVA, Alexander GUSEV, Olga ZAYTSEVA, Olga SHEINA, Alexey TKACHEV, Elena KUZNETSOVA, Elena LAZAREVA, Galina ONISHCHENKO, Alexey FEOFANOV, Mikhail KIRPICHNIKOV

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 132-138 doi: 10.1007/s11705-012-1290-5

Abstract: We have studied the effect of the engineered nanomaterial Taunit, containing multiwalled carbon nanotubes (MWCNTs), on the growth of seedlings and investigated whether affected plants uptake and accumulate MWCNTs. We found that 100 μg/mL and 1000 μg/mL of Taunit stimulated the growth of roots and stems, and enhanced the peroxidase activity in these parts of plants. Microscopy studies showed the presence of MWCNTs in the root and leaf tissues of seedlings exposed to Taunit, suggesting that MWCNTs have a capacity to penetrate the cell walls, accumulate in roots and translocate to the leaves. Thus the stimulating effect of MWCNTs on seedlings of may be associated with the primary uptake and accumulation of MWCNTs by plant roots followed by translocation to the other plant tissues.

Keywords： multiwalled carbon nanotubes     plants     electron microscopy    

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Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 226-238 doi: 10.1007/s11783-013-0582-4

Abstract: Subcellular distributions and chemical forms of cadmium (Cd) in the leaves, stems and roots were investigated in low-Cd accumulation cultivars and high-Cd accumulation cultivars of pakchoi ( L.). Root cell wall played a key role in limiting soil Cd from entering the protoplast, especially in the low-Cd cultivars. The high-Cd cultivars had significantly higher leaf and stem Cd concentrations than the low-Cd cultivars in cell wall fraction, chloroplast/trophoplast fraction, organelle fraction and soluble fraction. In low-Cd cultivars, which were more sensitive and thus had greater physiological needs of Cd detoxification than high-Cd cultivars, leaf vacuole sequestrated higher proportions of Cd. Cd in the form of pectate/protein complexes (extracted by 1 mol·L NaCl) played a decisive role in Cd translocation from root to shoot, which might be one of the mechanisms that led to the differences in shoot Cd accumulation between the two types of cultivars. Furthermore, the formation of Cd-phosphate complexes (extracted by 2% HAc) was also involved in Cd detoxification within the roots of pakchoi under high Cd stress, suggesting that the mechanisms of Cd detoxification might be different between low- and high-Cd cultivars.

Keywords： cadmium (Cd)     low-Cd cultivar     pakchoi (Brassica chinensis L.)     subcellular distribution     chemical forms    

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Research on physical-chemical and biochemical combined technology in the treatment of refractory petrochemical

Tian Zhiyong,Tu Xiang,Song Yonghui,Xin Wang,Li Fayun

Strategic Study of CAE 2013, Volume 15, Issue 3,   Pages 80-87

Abstract:

The lab-scale and pilot-scale physical-chemical and biochemical combinedremoval performance could be improved significantly by reasonable coupling of physical-chemical and biochemical

Keywords： refractory     dry-spun     acrylic fiber wastewater     physical-chemical     biochemical     combined treatment    

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BIOINSECTICIDES AS FUTURE MAINSTREAM PEST CONTROL AGENTS: OPPORTUNITIES AND CHALLENGES

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 82-97 doi: 10.15302/J-FASE-2021404

Abstract: This review summarizes current progress on bioinsecticides which are categorized as biochemical insecticides

Keywords： biochemical insecticide / bioinsecticide / microbial bioinsecticides / plant-incorporated protectant    

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Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 2,   Pages 129-141 doi: 10.1007/s11709-007-0014-2

Abstract: The assumption and problem of the mode-superposition response spectrum method in seismic design codeThe progresses on the mode superposition response spectrum theory are discussed.multiple-support seismic excitations and deducing corresponding method; 4) the approach for calculation of seismic responseof the non-classically damped system with overcritical damping and the calculation method of seismic response

Keywords： generalization     classical damping     mode-superposition response     calculation formula     damping theory    

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Temporal changes in the characteristics of algae in Dianchi Lake, Yunnan Province, China

Ruixia SHEN,Chunyan TIAN,Zhidan LIU,Yuanhui ZHANG,Baoming LI,Haifeng LU,Na DUAN

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3,   Pages 266-275 doi: 10.15302/J-FASE-2015064

Abstract: The algal biochemical components varied over the period; lipids from 0.7% to 2.1% ash-free dry weightThis study demonstrated remarkable temporal changes in the biochemical composition and biodiversity of

Keywords： algal blooms     temporal change     biochemical property     biodiversity     hydrothermal liquefaction    

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Confining pressure effect on dynamic response of high rockfill dam

Xuexing CAO, Yunlong HE, Kun XIONG,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 1,   Pages 116-126 doi: 10.1007/s11709-010-0014-5

Abstract: A corresponding computational procedure was compiled and applied in the dynamic response analysis of

Keywords： confining pressure effect     high rockfill dam     dynamic response     Hardin-Drnevich constitutive model    

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Topology optimization of transient problem with maximum dynamic response constraint using SOAR scheme

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 3,   Pages 593-606 doi: 10.1007/s11465-021-0636-4

Abstract: method for the continuum topology optimization of transient vibration problem with maximum dynamic responseAn aggregated index in the form of an integral function is presented to cope with the maximum responseThrough comparison with the corresponding static response from the final designs, the optimized results

Keywords： topology optimization     solid isotropic material with penalization     transient response     aggregation function    

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Dynamic response of precast segmental bridge columns under heavy truck impact

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 3,   Pages 327-349 doi: 10.1007/s11709-023-0911-z

Abstract: Considering the wide application of precast segmental bridge columns (PSBCs) in engineering practice, impact-resistant performance has gained significant attention. However, few studies have focused on PSBCs subjected to high-energy impacts caused by heavy truck collisions. Therefore, the behavior of PSBCs under a heavy truck impact was investigated in this study using high-fidelity finite element (FE) models. The detailed FE modeling methods of the PSBCs and heavy trucks were validated against experimental tests. The validated modeling methods were employed to simulate collisions between PSBCs and heavy trucks. The simulation results demonstrated that the engine and cargo caused two major peak impact forces during collision. Subsequently, the impact force, failure mode, displacement, and internal force of the PSBCs under heavy truck impacts were scrutinized. An extensive study was performed to assess the influence of the section size, truck weight, impact velocity, and number of precast segments on the impact responses. The truck weight was found to have a minor effect on the engine impact force. Damage was found to be localized at the bottom of the three segments, with the top remaining primarily undamaged. This parametric study demonstrated that larger cross-sections may be a preferred option to protect PSBCs against the impact of heavy trucks.

Keywords： precast segmental bridge columns     heavy truck     collision     dynamic response    

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Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 221-236 doi: 10.1007/s11705-021-2061-y

Abstract: For utilizing such time-resolved data to model the dynamic behavior, dynamic response surface methodology

Keywords： data-driven modeling     pharmaceutical organic synthesis     Lasso regression     dynamic response surface methodology    

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Title Author Date Type Operation

Digital microfluidics: A promising technique for biochemical applications

He WANG, Liguo CHEN, Lining SUN

Journal Article

Potential of electron transfer and its application in dictating routes of biochemical processes associated

Journal Article

Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary cirrhosis: a 2-year follow-up study

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Journal Article

Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine

Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI

Journal Article

Uptake and accumulation of multiwalled carbon nanotubes change the morphometric and biochemical characteristics

Elena SMIRNOVA, Alexander GUSEV, Olga ZAYTSEVA, Olga SHEINA, Alexey TKACHEV, Elena KUZNETSOVA, Elena LAZAREVA, Galina ONISHCHENKO, Alexey FEOFANOV, Mikhail KIRPICHNIKOV

Journal Article

Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Journal Article

Research on physical-chemical and biochemical combined technology in the treatment of refractory petrochemical

Tian Zhiyong,Tu Xiang,Song Yonghui,Xin Wang,Li Fayun

Journal Article

BIOINSECTICIDES AS FUTURE MAINSTREAM PEST CONTROL AGENTS: OPPORTUNITIES AND CHALLENGES

Journal Article

Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

Journal Article

Temporal changes in the characteristics of algae in Dianchi Lake, Yunnan Province, China

Ruixia SHEN,Chunyan TIAN,Zhidan LIU,Yuanhui ZHANG,Baoming LI,Haifeng LU,Na DUAN

Journal Article

Confining pressure effect on dynamic response of high rockfill dam

Xuexing CAO, Yunlong HE, Kun XIONG,

Journal Article

Topology optimization of transient problem with maximum dynamic response constraint using SOAR scheme

Journal Article

Dynamic response of precast segmental bridge columns under heavy truck impact

Journal Article

Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis

Journal Article

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Journal Article